Development of a Murine Model of Accelerated Senescence, SAM
نویسندگان
چکیده
منابع مشابه
Biochemical characteristics of lungs in senescence-accelerated mouse (SAM).
This study examined age-related biochemical changes of the lung in an animal model of senile lung, senescence-accelerated mouse (SAM). Bronchoalveolar lavage (BAL) was performed on two strains of SAM, the senescence-prone strain (SAM P2) and the senescence-resistant strain (SAM R1), as well as on normal ageing C57 black mice (C57BL), aged 1-24 months. Elastase-like and elastase inhibitory activ...
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deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
[Anti-aging studies on the senescence accelerated mouse (SAM) strains].
Senescence accelerated mouse (SAM), a murine model of accelerated senescence, was established by Toshio Takeda and colleagues. SAM consists of series of SAMP (prone) and SAMR (resistant) lines. All SAMP lines (from SAMP1 to SAMP11) are characterized by accelerated accumulation of senile features, earlier onset and faster progress of age-associated pathological phenotypes, such as amyloidosis, i...
متن کاملHepatic gene expression changes in an experimental model of accelerated senescence: the SAM-P8 mouse.
The senescence-accelerated mouse (SAM) is an experimental model of aging, established through phenotypic selection from a common genetic pool of AKR/J mice. Here we use complementary DNA microarray, Western blot, and electrophoretic mobility shift assay to consider whether changes in liver gene expression observed in 5-month-old SAM-prone 8 (P8) mice, compared to SAM-R1 controls, are similar to...
متن کاملSenescence-accelerated Mouse (SAM): With Special Reference to Development and Pathological Phenotypes.
ated aging. J Gerontol Biol Sci 49:B245. Klinger MM, MacCarter GD, Boozer CN. 1996. Body weight and composition in the Sprague Dawley rat: Comparison of three outbred sources. Lab Anim Sci 46:67-70. Lipman RD, Chrisp CE, Hazzard DG, Branson RT. 1996. Pathologic characterization of Brown Norway, Brown Norway X Fischer 344, and Fischer 344 X Brown Norway rats with relation to age. J Gerontol Biol...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Association of Animal Models for Human Diseases
سال: 1989
ISSN: 0911-2057,1884-4189
DOI: 10.1538/expanim1985.5.1